Our goal is to develop microbial biotechnology concepts that can ultimately be applied to solve grand challenges such as pollution and climate change. Our scientific focus is on the development of microbial catalysts for the bio-based production of chemicals, and the fundamental understanding of the underlying cellular processes. Our main workhorses are bacteria from the genus Pseudomonas and fungi from the Ustilaginaceae family. Our methods revolve around synthetic biology, metabolic engineering, laboratory evolution, systems analysis, and bioprocess technology.