Bacterial Networks and Interactions
We study the interaction between bacteria and the viruses (phages) infecting them. Our goal is to gain fundamentally new insights into the bacterial immune system and to apply this knowledge for the development of innovative applications in synthetic biology and biotechnology. Furthermore, we are interested in the design and dynamics of complex regulatory networks enabling microorganisms to adapt to ever changing environments and to discriminate between ‘self’ and ‘foreign’. Microbial model hosts used in our laboratory include the biotechnological platform strain Corynebacterium glutamicum and Streptomyces – the source of most of our antibiotics.
Phage-host interaction: We study how phages target key regulatory hubs of the host cell and how bacteria protect themselves against this attack.
Gene regulatory networks: We study the design and architectures of regulatory networks enabling bacteria to respond to environmental stresses and to interact with other microbes.
Evolutionary engineering: We are harnessing the power of evolution for the development of microbial production strains by using synthetic regulatory circuits and transcription factor-based biosensors.
Prof. Dr. Julia Frunzke
Building 15.4 / Room 239
News and Highlights
Tom publishes a paper in Current Opinion in Microbiology doi: 10.1016/j.mib.2023.102314
Vikas publishes a paper in Scientific Reports doi: 10.1038/s41598-023-30829-z
Larissa successfully defends her PhD – Congratulations!
SFB1535 MibiNet - Successful start with kick-off meeting
Tom publishes a paper in microLife, doi: https://doi.org/10.1093/femsml/uqad002
Aileen successfully defends her PhD - Congratulations!
Annual Group Retreat Waimés, BE
The SPP 2330 project “Going-viral 2022”, a phage-hunting experiment for school kids starts!
The Annual SPP 2330 Meeting was held in Rösrath https://spp2330.de/news/annual-spp-2330-meeting-2022-2/
Aileen publishes a paper in frontiers in Microbiology, doi: 10.3389/fmicb.2022.997448
Aileen wins a poster prize at BacNet22!
Aël and Larissa publish a review in Trends in Microbiology, doi: https://doi.org/10.1016/j.tim.2022.08.001
Sebastian publishes a paper in Viruses, doi: https://doi.org/10.3390/v14071449
Johanna receives a poster prize at the ISBA Meeting. Congratulations!