Publikationen 2019

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Autophagy-Related Proteins GABARAP and LC3B Label Structures of Similar Size but Different Shape in Super-Resolution Imaging
Molecules 24(9), 1833 - () [10.3390/molecules24091833] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils
eLife 8, e46112 () [10.7554/eLife.46112] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Molecular adaptations of NADP-malic enzyme for its function in C4 photosynthesis in grasses
Nature plants 5(7), 755 - 765 () [10.1038/s41477-019-0451-7] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Large-scale, dynamin-like motions of the human guanylate binding protein 1 revealed by multi-resolution simulations
PLoS Computational Biology 15(10), e1007193 - () [10.1371/journal.pcbi.1007193] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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C-terminal Modulators of Heat Shock Protein of 90 kDa (HSP90): State of Development and Modes of Action
Bioorganic & medicinal chemistry 27(21), 115080 () [10.1016/j.bmc.2019.115080] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Pseudomonas aeruginosa esterase PA2949, a bacterial homolog of the human membrane esterase ABHD6: expression, purification and crystallization
Acta crystallographica / F Structural biology communications Section F F75(4), 270 - 277 () [10.1107/S2053230X19002152] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Posttranslational modification of the NADP-malic enzyme involved in C4 photosynthesis fine-tunes the enzymatic activity during the day
The plant cell 31(10), 2525-2539 () [10.1105/tpc.19.00406] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Automated and Optimally FRET-Assisted Structural Modeling
Biophysical journal 116(3, Suppl 1) 333a - () [10.1016/j.bpj.2018.11.1815] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Converging a Knowledge-Based Scoring Function: DrugScore2018
Journal of chemical information and modeling 59(1), 509–521 () [10.1021/acs.jcim.8b00582] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Nutrient exchange in arbuscular mycorrhizal symbiosis from a thermodynamic point of view
The new phytologist 222(2), 1043-1053 () [10.1111/nph.15646] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers
Scientific reports 9(1), 5715 () [10.1038/s41598-019-41993-6] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation
Chemistry and physics of lipids 220, 57 - 65 () [10.1016/j.chemphyslip.2019.02.009] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Unique structure and function of viral rhodopsins
Nature Communications 10(1), 4939 () [10.1038/s41467-019-12718-0] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Smad7 in intestinal CD4 + T cells determines autoimmunity in a spontaneous model of multiple sclerosis
Proceedings of the National Academy of Sciences of the United States of America 116(51), 25860 - 25869 () [10.1073/pnas.1905955116] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Partially inserted nascent chain unzips the lateral gate of the Sec translocon
EMBO reports 20, e48191 () [10.15252/embr.201948191] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Calcium-promoted interaction between the C2-domain protein EHB1 and metal transporter IRT1 inhibits Arabidopsis iron acquisition
Plant physiology 180(3), 1564-1581 () [10.1104/pp.19.00163]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication
The journal of biological chemistry 294, 7388-7402 () [10.1074/jbc.RA119.007656]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Isoform-specific Inhibition of N-methyl-D-aspartate Receptors by Bile Salts
Scientific reports 9(1), 10068 () [10.1038/s41598-019-46496-y] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Hyperpolarized MAS NMR of unfolded and misfolded proteins
Solid state nuclear magnetic resonance 98, 1-11 () [10.1016/j.ssnmr.2018.12.003] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site
Scientific reports 9(1), 14167 () [10.1038/s41598-019-48155-8] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Synthesis of peptoid-based class I selective histone deacetylase inhibitors with chemosensitizing properties
Journal of medicinal chemistry 62(24), 11260-11279 () [10.1021/acs.jmedchem.9b01489]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Structure of the SLy1 SAM homodimer reveals a new interface for SAM domain self-association
Scientific reports 9(1), 54 () [10.1038/s41598-018-37185-3] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Biochemical and structural characterization of murine GBP7, a guanylate binding protein with an elongated C-terminal tail
Biochemical journal 476(21), 3161 - 3182 () [10.1042/BCJ20190364] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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N 6 -modified cAMP derivatives that activate protein kinase A also act as full agonists of murine HCN2 channels
The journal of biological chemistry 294, 17978-17987 () [10.1074/jbc.RA119.010246] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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JAK2 p.G571S in B-cell precursor acute lymphoblastic leukemia: a synergizing germline susceptibility
Leukemia 33, 2331–2335 () [10.1038/s41375-019-0459-z] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Oral and intravenous transmission of α-synuclein fibrils to mice
Acta neuropathologica 138(4), 515 - 533 () [10.1007/s00401-019-02037-5] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Enantioselective total synthesis of altersolanol A and N
Bioorganic & medicinal chemistry 27(13), 2991 - 2997 () [10.1016/j.bmc.2019.04.033] BibTeX | EndNote: XML, Text | RIS

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Integrated NMR, Fluorescence, and Molecular Dynamics Benchmark Study of Protein Mechanics and Hydrodynamics
The journal of physical chemistry <Washington, DC> / B B, Condensed matter, materials, surfaces, interfaces & biophysical 123(7), 1453 - 1480 () [10.1021/acs.jpcb.8b08903] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Co-culture of the fungus Fusarium tricinctum with Streptomyces lividans induces production of cryptic naphthoquinone dimers
RSC Advances 9(3), 1491 - 1500 () [10.1039/C8RA09067J] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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A thermostable flavin-based fluorescent protein from Chloroflexus aggregans : a framework for ultra-high resolution structural studies
Photochemical & photobiological sciences 18(7), 1793 - 1805 () [10.1039/C9PP00067D] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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GI infections are associated with an increased risk of Parkinson’s disease
Gut 69(6), () [10.1136/gutjnl-2019-318822] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Rational Drug Design of Peptide-Based Therapies for Sickle Cell Disease
Molecules 24(24), 4551 - () [10.3390/molecules24244551] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Novel Fluorescent Cyclic Nucleotide Derivatives to Study CNG and HCN Channel Function
Biophysical journal 116(12), 2411-2422 () [10.1016/j.bpj.2019.05.006] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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A FRET-based biosensor for the quantification of glucose in culture supernatants of mL scale microbial cultivations
Microbial cell factories 18(1), 143 () [10.1186/s12934-019-1193-y] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Effects of in vivo conditions on amyloid aggregation
Chemical Society reviews 48(14), 3946 - 3996 () [10.1039/C8CS00034D]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Mechanism of Fibril and Soluble Oligomer Formation in Amyloid Beta and Hen Egg White Lysozyme Proteins
The journal of physical chemistry <Washington, DC> / B B, Condensed matter, materials, surfaces, interfaces & biophysical 123(27), 5678 - 5689 () [10.1021/acs.jpcb.9b02338] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents
PLoS pathogens 15(8), e1007978 - () [10.1371/journal.ppat.1007978] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Small-molecule inhibitors of nisin resistance protein NSR from the human pathogen Streptococcus agalactiae
Bioorganic & medicinal chemistry 27(20), 115079 () [10.1016/j.bmc.2019.115079] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Biallelic mutation of human SLC6A6 encoding the taurine transporter TAUT is linked to early retinal degeneration
The FASEB journal 33(10), 11507–11527 () [10.1096/fj.201900914RR]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Fluorescent analogs of peptoid-based HDAC inhibitors: Synthesis, biological activity and cellular uptake kinetics
Bioorganic & medicinal chemistry 27(19), 115039 - () [10.1016/j.bmc.2019.07.055]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Design, Synthesis and Biological Evaluation of β-Peptoid-Capped HDAC Inhibitors with Anti-Neuroblastoma and Anti-Glioblastoma Activity
MedChemComm 10(7), 1109-1115 () [10.1039/C8MD00454D]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy
Nature Communications 10(1), 3754 () [10.1038/s41467-019-11320-8] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5
Frontiers in pharmacology 10, 400 () [10.3389/fphar.2019.00400] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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The Relevance of Conformational Entropy for Protein Ligand Interactions: the Case of Biotin and Streptavidin
Biophysical journal 116(3), 151a - () [10.1016/j.bpj.2018.11.840] BibTeX | EndNote: XML, Text | RIS

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Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer’s Mice with Full-blown Pathology
Molecular neurobiology 56(3), 2211-2223 () [10.1007/s12035-018-1209-3] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Deceleration of the neurodegenerative phenotype in pyroglutamate-Aβ accumulating transgenic mice by oral treatment with the Aβ oligomer eliminating compound RD2
Neurobiology of disease 124, 36-45 () [10.1016/j.nbd.2018.10.021] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Cosolvent-enhanced Sampling and Unbiased Identification of Cryptic Pockets Suitable for Structure-based Drug Design
Journal of chemical theory and computation 15(5), 3331–3343 () [10.1021/acs.jctc.8b01295] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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PACKMOL-Memgen: A Simple-To-Use, Generalized Workflow for Membrane-Protein–Lipid-Bilayer System Building
Journal of chemical information and modeling 59(6), 2522-2528 () [10.1021/acs.jcim.9b00269] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Structural Model of the ETR1 Ethylene Receptor Transmembrane Sensor Domain
Scientific reports 9(1), 8869 () [10.1038/s41598-019-45189-w] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Structural Studies of Autophagy-Related Proteins
Autophagy / Ktistakis, Nicholas (Editor) Chapter 2 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-4939-8872-3=978-1-4939-8873-0 ; doi:10.1007/978-1-4939-8873-0 New York, NY : Springer New York, Methods in Molecular Biology 1880, 17 - 56 () [10.1007/978-1-4939-8873-0_2]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Automated Markov state models for molecular dynamics simulations of aggregation and self-assembly
The journal of chemical physics 150(11), 115101 - () [10.1063/1.5083915] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels
Scientific reports 9(1), 526 () [10.1038/s41598-018-36717-1] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Author Correction: The highly GABARAP specific rat monoclonal antibody 8H5 visualizes GABARAP in immunofluorescence imaging at endogenous levels
Scientific reports 9(1), 19221 () [10.1038/s41598-019-55814-3] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Proton exchange in aqueous urea solutions measured by water‐exchange (WEX) NMR spectroscopy and chemical exchange saturation transfer (CEST) imaging in vitro
Magnetic resonance in medicine 82(3), 935-947 () [10.1002/mrm.27778] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Transition Metal Ion Interactions with Disordered Amyloid-β Peptides in the Pathogenesis of Alzheimer’s Disease: Insights from Computational Chemistry Studies
Journal of chemical information and modeling 59(5), 1782 - 1805 () [10.1021/acs.jcim.8b00983] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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FK506 resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 involves mutations in the transmembrane domains and extracellular loops
Antimicrobial agents and chemotherapy 63(1), e01146-18 () [10.1128/AAC.01146-18] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats
Acta neuropathologica 138(4), 535 - 550 () [10.1007/s00401-019-02040-w] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Reconstitution and NMR Characterization of the Ion-Channel Accessory Subunit Barttin in Detergents and Lipid-Bilayer Nanodiscs
Frontiers in molecular biosciences 6, 13 () [10.3389/fmolb.2019.00013] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Unusual features of the c-ring of F1FO ATP synthases
Scientific reports 9(1), 18547 () [10.1038/s41598-019-55092-z] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells
Bioorganic & medicinal chemistry 27(19), 115044 () [10.1016/j.bmc.2019.115044] BibTeX | EndNote: XML, Text | RIS

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Interaction of carbohydrate-binding modules with poly(ethylene terephthalate)
Applied microbiology and biotechnology 103(12), 4801 - 4812 () [10.1007/s00253-019-09760-9] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Surprising Non-Additivity of Methyl-Groups in Drug-Kinase Interaction
ACS chemical biology 14(12), 2585-2594 () [10.1021/acschembio.9b00476]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Basal Histamine H4 Receptor Activation: Agonist Mimicry by the Diphenylalanine Motif
Chemistry - a European journal 25(64), 14613-14624 () [10.1002/chem.201902801]  Download fulltext Files BibTeX | EndNote: XML, Text | RIS

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Do We Need Anti-Prion Compounds to Treat Alzheimer’s Disease?
Molecules 24(12), 2237 - () [10.3390/molecules24122237] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Interference with Amyloid-β Nucleation by Transient Ligand Interaction
Molecules 24(11), 2129 - () [10.3390/molecules24112129] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Solution-Based Determination of Dissociation Constants for the Binding of Aβ42 to Antibodies
ChemistryOpen 8(7), 989 - 994 () [10.1002/open.201900167] OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Toward the Mode of Action of the Clinical Stage All- d -Enantiomeric Peptide RD2 on Aβ42 Aggregation
ACS chemical neuroscience 10(12), 4800 - 4809 () [10.1021/acschemneuro.9b00458] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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Amperometric Aptasensor for Amyloid-β Oligomer Detection by Optimized Stem-Loop Structures with an Adjustable Detection Range
ACS sensors 4(11), 3042 - 3050 () [10.1021/acssensors.9b01630] Embargoed OpenAccess  Download fulltext Files  Download fulltextFulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Letzte Änderung: 23.05.2022