Johannes Otten

Mahalakshmi Venugopal

Alumni

Sylvia Tandetzki – Hochschule Fresenius

Michelle Billig – University of Applied Sciences Bonn-Rhein-Sieg

Lukas Rautenburg – Univeristaet Duisburg, Essen

Sophie Deselaers – Heinrich Heine Universitaet Duesseldorf; current address ETH Zurich

1. DISCARD - DISC1: Its Structure, Causes of Aggregation and Relevance to Disease: A collaborative effort with the Bradshaw group at the University of Rijeka, Croatia. Our efforts entail biophysical characterization of DISC1 pathophysiolgy and its implications to cellular physiology. The research activity is supported by the Alexandre von Humboldt Research Group Linkage

2. Combining clinical qNMR metabolomics, data analytics and machine learning approaches as a fast and reliable schizophrenia diagnostic tool: This collaborative effort with the systems metabolomics group of Prof. Dr. Gabi Kastemüller at the Helmholtz zentrum Muenchen encompasses investigating the potential of qNMR metabolomics and data analytics to study the biochemical basis of schizophrenia. The project is supported by the Helmholtz Information & Data Science Academy (HIDA-Trainee Network).

3. NMR metabolomics on clinically relevant schizophrenia smaples is being pursued with the collaborative effort of The Neuromodulation of Emotion (NEMO) Research Group in Karl-Jaspers-Klinik, Universitätsklinik für Psychiatrie und Psychotherapie at Carl von Ossietzky Universität Oldenburg institute is led by Prof. Dr. Dr. Rene Hurlemann

4. Unravelling the biochemical basis of sleep disorders is a research activity that is being pursued in collaboration with Prof. Dr. David Elmenhorst at the Institute of Neuroscience and Medicine (INM-2) at the Forschungszentrum Juelich GmbH

5. In collaboration with the group of Prof. Pavlik Lettinga (IBI-4) at the Forschungszentrum Juelich GmbH , we are investigating;The role of α-syn and Aβ mediated RBC aggregation and lysis in (non-)-cerebral amyloid angiopathy.

https://www.fz-juelich.de/en/news/archive/press-release/2022/2022-01-11-disc-en

https://www.hhu.de/die-hhu/presse-und-marketing/aktuelles/pressemeldungen-der-hhu/news-detailansicht/neue-studie-zeigt-moegliche-ursachen-von-psychiatrischen-erkrankungen

Cukkemane, A., Becker, N., Zielinski, M., Frieg, B., Lakomek, N.A., Heise, H., Schröder, G.F., Willbold, D., Weiergräber, O.H. (2021) Conformational heterogeneity coupled with beta-fibril formation of a scaffold protein involved in chronic mental illnesses. Transl. Psychiatry 11, 639. https://doi.org/10.1038/s41398-021-01765-1

Cukkemane, A., Kumar, P., and Sathyamoorthy, B. (2020). Understanding the role of synbiotics in functional foods and dietary therapeutics for health, communicable and non-communicable diseases using metabolomics footprint studies. Food Res. Int. 128: 108679 https://doi.org/10.1016/j.foodres.2019.108679

Ukale, U.D., Bhagwat R.V, Upadhyay S.K, Cukkemane, N., and Cukkemane, A.A. (2016). Metabolic analysis of liquid formulations of organic manures and its influence on growth and yield of Solanum lycopersicum L. (tomato) crop in field. Biocatal. Agric. Biotechnol. 8: 50-54. https://doi.org/10.1016/j.bcab.2016.08.007

Cukkemane, A. and Baldus, M. (2013). Structural characterization of a cyclic nucleotide-activated K⁺-channel and its lipid environment by using solid-state NMR spectroscopy. Chembiochem 14(14):1789-1798. https://doi.org/10.1002/cbic.201300182

Cukkemane, A., Gruter, B., Novak, K., Gensch, T., Boenigk, W., Gerharz, T., Kaupp, U.B., and Seifert, R. (2007). ”Subunits act independently in a cyclic nucleotide-activated K+-channel.” EMBO Reports 8: 749-755. https://doi.org/10.1038/sj.embor.7401025