Towards understanding the molecular pathomechanisms of schizophrenia

Re-igniting the embers of molecular psychiatry and its applications to schizophrenia research

1. Structural biology and biophysical characterization of schizophrenia protein risk factor Disrupted-in-Schizophrenia 1 (DISC1)

2. Biochemical profiling and qNMR metabolomics as a diagnostic application for schizophrenia

Über

Welcome to the research group of “The Unmelodramatics”.

I am Abhishek and my group’s research activities revolve around comprehending the molecular basis of the psychiatric disorder schizophrenia.

We are studying the the influence of protein risk-fators using a variety of structural biology tools such as X-ray crystallography, solid-state NMR spectroscopy and electron microscopy to comprehend the 3D architecture of the schizophrenia protein risk factor called Disrupted-in-schizophrenia-1 (DISC1); at the same time we are combining bio-physical tools such as iso-thermal titration calorimetry and dynamic light scattering to study the thermodynamics and kinetics of DISC1 aggregation; and surface-plasmon resonance and bio-layer interferometry to study the interaction of DISC1 with other relevant risk factors namely the NUDEL proteins and Lis1.

Forschungsthemen

  • Structural Biology
  • Biophysics
  • Metabolomics
  • Big Data Analytics

Kontakt

Dr. Abhishek Arun Cukkemane

IBI-7

Gebäude 05.8v / Raum 2019

+49 2461/61-9448

Members

Alumni

Ms. Sylvia Tandetzki – Hochschule Fresenius

Ms. Michelle Billig – University of Applied Sciences Bonn-Rhein-Sieg

Mr. Lukas Rautenburg – Univeristaet Duisburg, Essen

Ms. Sophie Deselaers – Heinrich Heine Universitaet Duesseldorf; current address ETH Zurich

Projekte
Selected Publications

Letzte Änderung: 28.07.2022