Publikationen Chemische Biologie der Proteinaggregation

Journal Article Heid, L. F. ; Kupreichyk, T.FZJ* ; Schützmann, M. P. ; Schneider, W. ; Stoldt, M.FZJ* ; Hoyer, W. (Corresponding author)
Nucleation of α-Synuclein Amyloid Fibrils Induced by Cross-Interaction with β-Hairpin Peptides Derived from Immunoglobulin Light Chains
International journal of molecular sciences 24(22), 16132 - (2023) [10.3390/ijms242216132]2023 OpenAccess Files BibTeX | EndNote: XML, Text | RIS

Journal Article Bannach, O. (Corresponding author)FZJ* ; Pils, M.FZJ* ; Dybala, A. ; Rehn, F.FZJ* ; Blömeke, L.FZJ* ; Bujnicki, T.FZJ* ; Kraemer-Schulien, V. M.FZJ* ; Hoyer, W. ; Riesner, D. ; Willbold, D.FZJ*
Development and implementation of an internal quality control sample to standardize oligomer-based diagnostics of Alzheimer's disease
Diagnostics 13(10), 1702 - (2023) [10.3390/diagnostics13101702]2023 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Altendorf, T.FZJ* ; Gering, I.FZJ* ; Santiago-Schübel, B.FZJ* ; Aghabashlou Saisan, S. ; Tamgüney, G.FZJ* ; Tusche, M.FZJ* ; Honold, D.FZJ* ; Schemmert, S.FZJ* ; Hoyer, W. ; Mohrlüder, J. (Corresponding author)FZJ* ; Willbold, D.FZJ*
Stabilization of Monomeric Tau Protein by All D-Enantiomeric Peptide Ligands as Therapeutic Strategy for Alzheimer’s Disease and Other Tauopathies
International journal of molecular sciences 24(3), 2161 - (2023) [10.3390/ijms24032161]2023 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Maity, D. ; Oh, Y. ; Gremer, L.FZJ* ; Hoyer, W. (Corresponding author)FZJ* ; Magzoub, M. ; Hamilton, A. D.
Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity.
Chemistry - a European journal 28(38), na/na (2022) [10.1002/chem.202201698]2022 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Maity, D. (Corresponding author) ; Oh, Y. ; Gremer, L.FZJ* ; Hoyer, W. (Corresponding author)FZJ* ; Magzoub, M. ; Hamilton, A. D. (Corresponding author)
Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity.
Chemistry - a European journal 28(38), e202200456 (2022) [10.1002/chem.202200456]2022 Files BibTeX | EndNote: XML, Text | RIS

Journal Article Törner, R. ; Kupreichyk, T.FZJ* ; Gremer, L.FZJ* ; Debled, E. C. ; Fenel, D. ; Schemmert, S.FZJ* ; Gans, P. ; Willbold, D.FZJ* ; Schoehn, G. ; Hoyer, W. (Corresponding author)FZJ* ; Boisbouvier, J. (Corresponding author)
Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin.
Nature Communications 13(1), 2363 (2022) [10.1038/s41467-022-30042-y]2022 Files Fulltext by OpenAccess repository Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

Journal Article Braczynski, A. K. ; Sevenich, M.FZJ* ; Gering, I.FZJ* ; Kupreichyk, T.FZJ* ; Agerschou, E. D. ; Kronimus, Y. ; Habib, P. ; Stoldt, M.FZJ* ; Willbold, D.FZJ* ; Schulz, J. B.FZJ* ; Bach, J.-P. ; Falkenburger, B. H. ; Hoyer, W. (Corresponding author)FZJ*
Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo
Biomolecules 12(3), 469 - (2022) [10.3390/biom12030469]2022 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Gomes, C. M. (Corresponding author) ; Hoyer, W. (Corresponding author)FZJ* ; Luo, J. (Corresponding author)
Editorial: The Biochemistry of Amyloids in Neurodegenerative Diseases, Volume I.
Frontiers in neuroscience 15, 819481 (2021) [10.3389/fnins.2021.819481]2021 Files Fulltext by Pubmed Central Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Szegő, É. M. ; Boß, F. ; Komnig, D. ; Gärtner, C. ; Höfs, L. ; Shaykhalishahi, H. ; Wördehoff, M. M. ; Saridaki, T. ; Schulz, J. B.FZJ* ; Hoyer, W.FZJ* ; Falkenburger, B. H. (Corresponding author)
A β-Wrapin Targeting the N-Terminus of α-Synuclein Monomers Reduces Fibril-Induced Aggregation in Neurons.
Frontiers in neuroscience 15, 696440 (2021) [10.3389/fnins.2021.696440]2021 Files Fulltext by OpenAccess repository Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

Journal Article Schützmann, M. P. ; Hasecke, F. ; Bachmann, S. ; Zielinski, M.FZJ* ; Hänsch, S. ; Schröder, G. F.FZJ* ; Zempel, H. (Corresponding author) ; Hoyer, W. (Corresponding author)FZJ*
Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting
Nature Communications 12(1), 4634 (2021) [10.1038/s41467-021-24900-4]2021 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Willbold, D. (Corresponding author)FZJ* ; Strodel, B.FZJ* ; Schröder, G. F.FZJ* ; Hoyer, W.FZJ* ; Heise, H.FZJ*
Amyloid-type Protein Aggregation and Prion-like Properties of Amyloids
Chemical reviews 121(13), 8285 - 8307 (2021) [10.1021/acs.chemrev.1c00196]2021 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article König, A. S.FZJ* ; Rösener, N.FZJ* ; Gremer, L.FZJ* ; Tusche, M.FZJ* ; Flender, D. ; Reinartz, E. ; Hoyer, W.FZJ* ; Neudecker, P.FZJ* ; Willbold, D.FZJ* ; Heise, H. (Corresponding author)FZJ*
Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy
The journal of biological chemistry 296, 100499 - (2021) [10.1016/j.jbc.2021.100499]2021 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Agerschou, E. D. ; Schützmann, M. P. ; Reppert, N. ; Wördehoff, M. M. ; Shaykhalishahi, H. ; Buell, A. K. ; Hoyer, W. (Corresponding author)FZJ*
β-Turn exchanges in the α-synuclein segment 44-TKEG-47 reveal high sequence fidelity requirements of amyloid fibril elongation
Biophysical chemistry 269, 106519 - (2021) [10.1016/j.bpc.2020.106519]2021 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Hasecke, F. ; Niyangoda, C. ; Borjas, G. ; Pan, J. ; Matthews, G. ; Muschol, M. (Corresponding author) ; Hoyer, W. (Corresponding author)FZJ*
Protofibril‐Fibril Interactions Inhibit Amyloid Fibril Assembly by Obstructing Secondary Nucleation
Angewandte Chemie / International edition 60(6), 3016-3021 (2021) [10.1002/anie.202010098]2021 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Rosenbach, H. ; Borggräfe, J.FZJ* ; Victor, J. ; Wuebben, C. ; Schiemann, O. ; Hoyer, W.FZJ* ; Steger, G.Extern* ; Etzkorn, M.FZJ* ; Span, I. (Corresponding author)FZJ*
Influence of monovalent metal ions on metal binding and catalytic activity of the 10–23 DNAzyme
Biological chemistry 402(1), 99 - 111 (2020) [10.1515/hsz-2020-0207]2020 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Maity, D. (Corresponding author) ; Kumar, S. ; AlHussein, R. ; Gremer, L.FZJ* ; Howarth, M. ; Karpauskaite, L. ; Hoyer, W.FZJ* ; Magzoub, M. ; Hamilton, A. D. (Corresponding author)
Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents
RSC chemical biology 1(4), 225-232 (2020) [10.1039/D0CB00086H]2020 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Agerschou, E. D. ; Borgmann, V. ; Wördehoff, M. M. ; Hoyer, W. (Corresponding author)FZJ*
Inhibitor and substrate cooperate to inhibit amyloid fibril elongation of α-synuclein
Chemical science 11(41), 11331 - 11337 (2020) [10.1039/D0SC04051G]2020 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Röder, C.FZJ* ; Kupreichyk, T.FZJ* ; Gremer, L.FZJ* ; Schäfer, L. U.FZJ* ; Pothula, K. R.FZJ* ; Ravelli, R. B. G. ; Willbold, D.FZJ* ; Hoyer, W.FZJ* ; Schröder, G. F. (Corresponding author)FZJ*
Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils
Nature structural & molecular biology 27(7), 660 - 667 (2020) [10.1038/s41594-020-0442-4]2020 Embargoed OpenAccess Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Rösener, N.FZJ* ; Gremer, L.FZJ* ; Wördehoff, M. M. ; Kupreichyk, T.FZJ* ; Etzkorn, M.FZJ* ; Neudecker, P.FZJ* ; Hoyer, W. (Corresponding author)FZJ*
Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus
Communications biology 3(1), 365 (2020) [10.1038/s42003-020-1085-z]2020 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Perez, C. ; Miti, T. ; Hasecke, F.FZJ* ; Meisl, G. ; Hoyer, W.FZJ* ; Muschol, M. ; Ullah, G. (Corresponding author)
Mechanism of Fibril and Soluble Oligomer Formation in Amyloid Beta and Hen Egg White Lysozyme Proteins
The journal of physical chemistry <Washington, DC> / B B, Condensed matter, materials, surfaces, interfaces & biophysical 123(27), 5678 - 5689 (2019) [10.1021/acs.jpcb.9b02338]2019 Embargoed OpenAccess Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Röder, C.FZJ* ; Vettore, N. ; Mangels, L. N.FZJ* ; Gremer, L.FZJ* ; Ravelli, R. B. G. ; Willbold, D.FZJ* ; Hoyer, W.FZJ* ; Buell, A. K. (Corresponding author) ; Schröder, G. (Corresponding author)FZJ*
Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy
Nature Communications 10(1), 3754 (2019) [10.1038/s41467-019-11320-8]2019 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Falke, M. ; Victor, J. ; Wördehoff, M. M. ; Peduzzo, A. ; Zhang, T.FZJ* ; Schröder, G. F.FZJ* ; Buell, A. K. ; Hoyer, W.FZJ* ; Etzkorn, M. (Corresponding author)FZJ*
α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation
Chemistry and physics of lipids 220, 57 - 65 (2019) [10.1016/j.chemphyslip.2019.02.009]2019 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Agerschou, E. D. ; Saridaki, T. ; Flagmeier, P. ; Galvagnion, C. ; Komnig, D. ; Nagpal, A. ; Gasterich, N. ; Heid, L. ; Prasad, V. ; Shaykhalishahi, H. ; Voigt, A. ; Willbold, D.FZJ* ; Dobson, C. M. ; Falkenburger, B. H. (Corresponding author) ; Hoyer, W. (Corresponding author)FZJ* ; Buell, A. K. (Corresponding author)
An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils
eLife 8, e46112 (2019) [10.7554/eLife.46112]2019 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Wördehoff, M. ; Hoyer, W. (Corresponding author)FZJ*
α-Synuclein Aggregation Monitored by Thioflavin T Fluorescence Assay
Bio-protocol 8(14), PMC6066150 (2018) [10.21769/BioProtoc.2941]2018 BibTeX | EndNote: XML, Text | RIS

Journal Article Orr, A. A. ; Shaykhalishahi, H. ; Mirecka, E. A. ; Jonnalagadda, S. V. R. ; Hoyer, W. (Corresponding author)FZJ* ; Tamamis, P. (Corresponding author)
Elucidating the multi-targeted anti-amyloid activity and enhanced islet amyloid polypeptide binding of β-wrapins
Computers & chemical engineering 116, 322 - 332 (2018) [10.1016/j.compchemeng.2018.02.013]2018 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Duggimpudi, S. ; Kloetgen, A. ; Maney, S. K. ; Münch, P. C. ; Hezaveh, K. ; Shaykhalishahi, H. ; Hoyer, W.FZJ* ; McHardy, A. C. ; Lang, P. A. ; Borkhardt, A. ; Hoell, J. I. (Corresponding author)
Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling
The journal of biological chemistry 293(40), 15359 - 15369 (2018) [10.1074/jbc.RA118.002243]2018 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Hasecke, F. ; Miti, T. ; Perez, C. ; Barton, J. ; Schölzel, D.FZJ* ; Gremer, L.FZJ* ; Grüning, C. S. R. ; Matthews, G. ; Meisl, G. ; Knowles, T. P. J. ; Willbold, D.FZJ* ; Neudecker, P.FZJ* ; Heise, H.FZJ* ; Ullah, G. ; Hoyer, W. (Corresponding author)FZJ* ; Muschol, M. (Corresponding author)
Origin of metastable oligomers and their effects on amyloid fibril self-assembly
Chemical science 9(27), 5937 - 5948 (2018) [10.1039/C8SC01479E]2018 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Viennet, T. ; Wördehoff, M. M. ; Uluca, B.FZJ* ; Poojari, C. ; Shaykhalishahi, H. ; Willbold, D.FZJ* ; Strodel, B.FZJ* ; Heise, H.FZJ* ; Buell, A. K. ; Hoyer, W.FZJ* ; Etzkorn, M. (Corresponding author)FZJ*
Structural insights from lipid-bilayer nanodiscs link α-Synuclein membrane-binding modes to amyloid fibril formation
Communications biology 1(1), 44 (2018) [10.1038/s42003-018-0049-z]2018 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Rösener, N.FZJ* ; Gremer, L.FZJ* ; Reinartz, E. ; König, A.FZJ* ; Brener, O.FZJ* ; Heise, H.FZJ* ; Hoyer, W.FZJ* ; Neudecker, P.FZJ* ; Willbold, D. (Corresponding author)FZJ*
A D-enantiomeric peptide interferes with hetero-association of amyloid-β oligomers and prion protein
The journal of biological chemistry 293, jbc.RA118.003116 - (2018) [10.1074/jbc.RA118.003116]2018 Embargoed OpenAccess Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Uluca, B.FZJ* ; Viennet, T.FZJ* ; Petrović, D.FZJ* ; Shaykhalishahi, H.FZJ* ; Weirich, F.FZJ* ; Gönülalan, A.FZJ* ; Strodel, B.FZJ* ; Etzkorn, M.FZJ* ; Hoyer, W.FZJ* ; Heise, H. (Corresponding author)FZJ*
DNP-Enhanced MAS NMR: A Tool to Snapshot Conformational Ensembles of α -Synuclein in Different States
Biophysical journal 114(7), 1614 - 1623 (2018) [10.1016/j.bpj.2018.02.011]2018 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Wördehoff, M. ; Shaykhalishahi, H. ; Groß, L. ; Gremer, L.FZJ* ; Stoldt, M.FZJ* ; Buell, A. ; Willbold, D.FZJ* ; Hoyer, W. (Corresponding author)FZJ*
Opposed effects of dityrosine formation in soluble and aggregated alpha-synuclein on fibril growth
Journal of molecular biology 429, 3018-3030 (2017) [10.1016/j.jmb.2017.09.005]2017 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Gremer, L.FZJ* ; Schölzel, D.FZJ* ; Schenk, C.FZJ* ; Reinartz, E. ; Labahn, J.FZJ* ; Ravelli, R. B. G. ; Tusche, M.FZJ* ; Lopez-Iglesias, C. ; Hoyer, W.FZJ* ; Heise, H.FZJ* ; Willbold, D. (Corresponding author)FZJ* ; Schröder, G. (Corresponding author)FZJ*
Fibril structure of amyloid-ß(1-42) by cryoelectron microscopy
Science 358, 116-119 (2017) [10.1126/science.aao2825]2017 Files BibTeX | EndNote: XML, Text | RIS

Journal Article Orr, A. A. ; Wördehoff ; Hoyer, W.FZJ* ; Tamamis, P. (Corresponding author)
Uncovering the Binding and Specificity of β-Wrapins for Amyloid-β and α-Synuclein
The journal of physical chemistry <Washington, DC> / B 120(50), 12781-12794 (2016) [10.1021/acs.jpcb.6b08485]2016 Files BibTeX | EndNote: XML, Text | RIS

Journal Article Mirecka, E. A. ; Feuerstein, S.FZJ* ; Gremer, L.FZJ* ; Schröder, G. F. ; Stoldt, M.FZJ* ; Willbold, D.FZJ* ; Hoyer, W. (Corresponding author)FZJ*
β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor
Scientific reports 6, 33474 - (2016) [10.1038/srep33474]2016 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Weirich, F.FZJ* ; Gremer, L.FZJ* ; Mirecka, E. A. ; Schiefer, S. ; Hoyer, W.FZJ* ; Heise, H. (Corresponding author)FZJ*
Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the β-Sheet Core
PLoS one 11(9), e0161243 (2016) [10.1371/journal.pone.0161243]2016 Files Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Contribution to a book Hoyer, W.FZJ* ; Shaykhalishahi, H. ; Ayalur-Karunakaran, S. ; Heise, H. (Corresponding author)FZJ*
Structural characterization of alpha-Synuclein amyloids
2015The Prion Phenomena in Neurodegenerative Diseases Hauppauge NY; USA : Nova Science Publishers 111-128 (2015)2015 BibTeX | EndNote: XML, Text | RIS

Journal Article Shaykhalishahi, H.FZJ* ; Gauhar, A. ; Wördehoff, M. M. ; Grüning, C. S. R. ; Klein, A. N.FZJ* ; Bannach, O.FZJ* ; Stoldt, M.FZJ* ; Willbold, D.FZJ* ; Härd, T. ; Hoyer, W. (Corresponding author)FZJ*
Contact between the β1 and β2 Segments of α-Synuclein that Inhibits Amyloid Formation
Angewandte Chemie / International edition 54(30), 8837 - 8840 (2015) [10.1002/anie.201503018]2015 Files BibTeX | EndNote: XML, Text | RIS

Journal Article Brener, O. ; Dunkelmann, T.FZJ* ; Gremer, L.FZJ* ; van Groen, T. ; Mirecka, E. A. ; Kadish, I. ; Willuweit, A.FZJ* ; Kutzsche, J.FZJ* ; Jürgens, D.FZJ* ; Rudolph, S. ; Tusche, M.FZJ* ; Bongen, P.FZJ* ; Pietruszka, J.FZJ* ; Oesterhelt, F. ; Langen, K.-J.FZJ* ; Demuth, H.-U. ; Janssen, A. ; Hoyer, W.FZJ* ; Funke, S. A. ; Nagel-Steger, L.FZJ* ; Willbold, D. (Corresponding author)FZJ*
QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers
Scientific reports 5, 13222 (2015) [10.1038/srep13222]2015 Files Fulltext Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

Journal Article Shaykhalishahi, H.FZJ* ; Mirecka, E. A. ; Gauhar, A. ; Grüning, C. S. R. ; Willbold, D.FZJ* ; Härd, T. ; Stoldt, M.FZJ* ; Hoyer, W. (Corresponding author)FZJ*
A β-Hairpin-Binding Protein for Three Different Disease-Related Amyloidogenic Proteins
ChemBioChem 16(3), 411 - 414 (2015) [10.1002/cbic.201402552]2015 Files BibTeX | EndNote: XML, Text | RIS

Contribution to a book Hoyer, W.FZJ* ; Heise, H. (Corresponding author)FZJ*
What does solid-state NMR tell us about Amyloid structures?
2013Amyloid fibrils and prefibrillar aggregates Weinheim : Wiley-VCH 39-62 (2013)2013 Fulltext BibTeX | EndNote: XML, Text | RIS

Letzte Änderung: 10.06.2022