Forschungszentrum Jülich

Alzheimer′ s Disease

Alzheimer´s disease is a progressive, neurodegenerative disorder and the most common type of dementia. Currently more than 24 million people are affected worldwide. Our research focusses on developing methods for pre-symptomatic diagnosis and new therapeutic approaches. More: Alzheimer′ s Disease …

Autophagy

Autophagy is a highly conserved mechanism in eukaryotes to degrade cellular components. Autophagy plays an important role both in the baseline turnover of intracellular proteins and organelles, as well as in the production of amino acids under starvation conditions. We investigate proteins that are involved in this process. More: Autophagy …

Virus-Host interactions

Virus-caused diseases are a major threat to human health. We focus on proteins coded by human immunodeficiency virus (HIV), Dengue virus (DENV), hepatitis C virus (HCV) and SARS-Coronavirus (SARS-CoV) the causative agents of acquired immunodeficiency syndrome (AIDS), of dengue fever, of chronic hepatitis, and of the severe acute respiratory syndrome (SARS), respectively. More: Virus-Host interactions …

Nanodiscs – Tool for membrane protein studies

Nanodiscs are self-assembled model membranes that resemble high density lipoprotein (HDL) particles. They consist of a small lipid bilayer patch and two copies of an amphipathic membrane scaffold protein (MSP) that shield the hydrophobic rim of the membrane fragment from water. More: Nanodiscs – Tool for membrane protein studies …