The project MetaProcess uses a multidisciplinary approach to generate stable carboligase and transaminase variants for the industrial enzymatic production of chiral amino alcohols as an eco-friendlier alternative to the traditional synthesis route based on petrochemical resources and metal-based catalysis reactions.The process will be implemented and upscaled for the production of metaraminol, an important vasoconstrictor. Former studies have already shown that the enzymatic biosynthesis of metaraminol using second-generation feedstocks is possible despite the early inactivation of the unoptimized biocatalysts. Rational design and directed evolution will be used to identify optimized variants, which will be integrated into a comprehensive industrial workflow for the sustainable and economically efficient production of chiral amino alcohols.
Contact: Prof. Holger Gohlke / Dr. Stephan Schott-Verdugo
Funded by the BioSC BOOST FUND 2.0