Computational next-generation biocatalysis

We use state-of-the-art protein structural modeling and multi-scale simulations techniques to model and simulate the dynamics of artificial multi-enzymatic assemblies catalyzing reactions of industrial interest. The implementation of a rational design approach combining theoretical predictions along with their experimental validation is designed to improve the stability and catalytic performance of such enzymatic cascades for use both in-vivo and in cell-free implementations

Multi-enzymatic cascade
Multi-scale approaches for engineering enzymatic cascades
B. David
Last Modified: 27.01.2023