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Wissenschaft online: „Axons and brain architectures: How to approach the human brain“, Prof. Kathleen Rockland, Department Anamoty & Neurobiology, Boston University School of Medicine

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19.04.2021 15:00 Uhr

Spitzenforschung vom heimischen Sofa aus erleben: Diese Möglichkeit bietet nun das Forschungszentrum Jülich an. Videokonferenzen mit Mitarbeitenden geben Ihnen einen Einblick in verschiedene Forschungsgebiete sowie die Karrieremöglichkeiten am Forschungszentrum.

Der Gastvortrag wird präsentiert vom Institut für Neurowissenschaften und Medizin INM-1 (Strukturelle und funktionelle Organisation des Gehirns). Frau Professor Dr. Med. Katrin Amunts, Leiterin des Instituts, wird in den Vortrag einführen.

Der Vortrag findet in englischer Sprache statt. Für den Termin gibt es einen gesonderten Link: https://webconf.fz-juelich.de/vip/bie-s1z-igz-fap

With rapid technological advances, the brain is becoming more and more accessible to scientific inquiry. Mapping is still at an early stage, however, and the human brain in particular remains the Mars Within.

The work of Brodmann and his contemporaries did much to lay the general scaffolding, but we are only now approaching the possibility of more formalized classification of cortical areas and, for cerebral cortex, of the basic structural features of layers, columns, and modules.

How do these identified elements interact? How are neurons and areas interconnected? At the anatomical mesoscale, which I will be emphasizing, results from animal experiments have generated principles such as convergence (one neuron receiving synapses from hundreds or thousands of others), divergence (one neuron sending hundreds or thousands of synapses to one or, often, multiple spatially separate targets), multiplicity of cell types (distinct classes and/or gradients?).

Increasingly apparent from whole brain visualization of single axons in rodent brains but arguably applicable to humans, is the diversity of branching patterns, where a given region sends projections to multiple targets, in various combinations.

Of the many challenges ahead is further understanding of the heterogeneous elements and how these operate and come together dynamically in what must be flexible roles and flexible routes in different behaviors and conditions.

Suggested Reading

K. Amunts et al. (2020) https://pubmed.ncbi.nlm.nih.gov/32732281/

A. Burkhalter (1993) https://pubmed.ncbi.nlm.nih.gov/8260814/

K.S. Rockland (2015) https://pubmed.ncbi.nlm.nih.gov/26042001/

K.S. Rockland (2020) https://pubmed.ncbi.nlm.nih.gov/31925518/

K.S. Rockland (2021) https://pubmed.ncbi.nlm.nih.gov/33603649/